Her blue skill, Solemn Seal, might benefit from disable but since it's directly tied to her white, I personally wouldn't put a lot of effort into getting more than one rune with disable as a primary. That's just me.
I have her with River and Mist sets. I focused on skill power, movement speed, cool down, and holy damage. I do have 1 minor rune with disable as primary. I've thought of swapping it out a few times just to see what might change, but she's very effective so not gonna mess with a combo that's working well. She's awesome and I use her a lot as part of my top 15 toons.